Novel Antimicrobial Peptides with High Anticancer Activity and Selectivity
نویسندگان
چکیده
منابع مشابه
Novel Antimicrobial Peptides with High Anticancer Activity and Selectivity
We describe a strategy to boost anticancer activity and reduce normal cell toxicity of short antimicrobial peptides by adding positive charge amino acids and non-nature bulky amino acid β-naphthylalanine residues to their termini. Among the designed peptides, K4R2-Nal2-S1 displayed better salt resistance and less toxicity to hRBCs and human fibroblast than Nal2-S1 and K6-Nal2-S1. Fluorescence m...
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1 Oral Health Cooperative Research Centre, Melbourne Dental School, University of Melbourne, Parkville, VIC, Australia, 2 Bio21 Institute, University of Melbourne, Parkville, VIC, Australia, 3 Faculty of Chemistry and Mineralogy, Institute of Bioanalytical Chemistry, Universität Leipzig, Leipzig, Germany, 4 Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany, 5 Exper...
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Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0126390